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Polyurethane-Polyurea Membranes for Blood Oxygenation

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Abstract:

The structural versatility of polyurethane based membranes is enhanced through the introduction of two soft segments to obtain new membranes with improved hemocompatibility. Crosslinked polyurethane/urea membranes with two soft segments were prepared by extending a polypropylene oxide-based tri-isocyanate terminated prepolymer (PU) with polybutadiene diol (PBDO). The ratio of PU to PBDO was 100/0 and 90/10. The membranes were characterised in terms of permeation towards O2 and CO2 and their hemocompatibility was evaluated through hemolysis and thrombosis experiments. It was found that the membrane with PBDO had the highest permeability to O2 and CO2 and it was non-hemolytic and less thrombogenic.

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Advanced Materials Forum III View Preview

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Periodical:

Materials Science Forum (Volumes 514-516)

Pages:

863-867

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.514-516.863

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Online since:

May 2006

Authors:

M. Isabel Pinto, Denise P. Queiroz, M. Helena Gil, Antonio Jorge Guiomar, Maria Norberta de Pinho

Keywords:

Blood Oxygenators, Hemocompatibility, Permeability, Segmented Polyurethane/Urea

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© 2006 Trans Tech Publications Ltd. All Rights Reserved

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References

[1] J.B. Park, R.S. Lakes: Biomaterials: An Introduction, 2nd Edition (Plenum Press, New York, 1992), p.280.

Google Scholar

[2] A. Korematsu, Y. Takemoto, T. Nakaya and H. Inone: Biomaterials Vol. 23 (2002), p.293.

Google Scholar

[3] K.Y. Chen, J.F. Kuo and C.Y. Chen: Biomaterials Vol. 21 (2000), p.161.

Google Scholar

[4] M. Levy and A.R. Hartmena: Int. J. Cardiol. Vol. 53 (1996) Suppl. p. S81.

Google Scholar

[5] G. Janvier, C. Baquey, C. Roth, N. Benillan, S. Bélisle and J. F. Hardy: Ann. Thorac. Surg. Vol. 62 (1996), p. (1926).

Google Scholar

[6] H.P. Wendel and G. Ziemer: Eur. J. Cardio-Thorac. Surg. Vol. 16 (1999), p.342.

Google Scholar

[7] T.C. Zhao and M.N. Pinho: Polymer Vol. 40 (1999), p.6089.

Google Scholar

[8] D.P. Queiroz and M.N. Pinho: Desalination Vol. 145 (2002), p.379.

Google Scholar

[9] ISO 10990-4: Biological Evaluation of Medical Devices - Part 4: Selection of Tests for Interaction with Blood (ISO, Geneva, Switzerland, 1999).

Google Scholar

[10] Standard Practices for Assessment of Haemolytic Properties of Materials: ASTM F 756-00 (ASTM, West Conshohocken, PA, USA, 2000).

Google Scholar

[11] Y. Imai and Y. Nose: J. Biomed. Mater. Res. Vol. 6 (1972), p.165.

Google Scholar

[12] Anticoagulant Citrate Dextrose Solution: U. S. Pharmacopeia Vol. 23 (1995), p.119.

Google Scholar

[13] M.F. Ferreira Marques, C. Lopes Gil, P.M. Gordo, Zs. Kajcsos, A.P. de Lima, D.P. Queiroz and M.N. de Pinho: Radiat. Phys. Chem. Vol. 68 (2003), p.573.

DOI: 10.1016/s0969-806x(03)00234-2

Google Scholar

[14] D.P. Queiroz, M.C. Gonçalves and M.N. Pinho: Tailoring of phase segregation structures in bi-soft segment urethane/urea polymer membranes. Submitted to J. Appl. Polym. Sci.

DOI: 10.1002/app.23876

Google Scholar

[15] C. -T. Zhao and M.N. Pinho MN: Polymer Vol. 40 (1999), p.6089.

Google Scholar

[16] D.P. Queiroz, A. M. Botelho do Rego and M.N. Pinho: Surface studies of bi-soft segmented polyurethane membranes by X-Ray Photoelectron Spectroscopy. Submitted to Polymer.

Google Scholar

[17] K. Nojima, K. Sanui, N. Ogata, Y.N. Yui, K. Kataoka and Y. Sakurai: Polymer Vol. 28 (1987), p.1017.

DOI: 10.1016/0032-3861(87)90179-0

Google Scholar

[18] N. Yiu, J. Tanaka, K. Sanui, N. Ogata, K. Kataoka, T. Okano and Y. Sakurai: Polym. J. Vol. 16 (1984), p.119.

Google Scholar