Construction of Self-Organized Interface via Monodisperse Block Copolypeptide Amphiphile

T. Niwa; Masayoshi Tanaka; Takatoshi Kinoshita

doi:10.4028/www.scientific.net/AMR.11-12.635

Paper Titles

Preparation and Characterization of RF/SiO₂ Hybrid Aerogel by Sol-Gel Method
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Organization of Photosynthetic Antenna Complex in Lipid Bilayers
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Preparation and Optical Characterization of Particle Multilayer with Coherent Structure
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Inorganic-Organic Thin-Layers which Transform Bio-Molecule Binding into Visible Color Change
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Construction of Self-Organized Interface via Monodisperse Block Copolypeptide Amphiphile
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Kinetics of Supramolecular Polymerization: MSOA and HG Mechanisms
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Synthesis of Amphiphilic Diblock Copolymer of Methoxy Poly(ethylene glycol)-b-polyester and Its Self-Assemble Behavior
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Effect of Rolling Deformation on Microstructure of AZ31 Magnesium Alloy
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Microstructure and Mechanical Properties of AZ31B Magnesium Alloy Sheets Prepared by Extruding and Rolling
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Construction of Self-Organized Interface via Monodisperse Block Copolypeptide Amphiphile

Abstract:

In order to construct an intelligent functional nano-interface, the self-organized structure of Langmuir-Blodgett (LB) film was investigated by atomic force microscopy (AFM). As a building block, a monodisperse loop-helix-helix triblock copolypeptide containing the helix of which hydrophobic L-leucine residues align on a single face, “leucine zipper”, was synthesized by recombinant DNA techniques with a designed amino acid sequence. AFM observation on the surface structure of LB films constructed at surface pressures of 2, 5 and 18 mN/m revealed that structural transition from ring- or disk-like aggregations to a lane-like fabrication occurred with compression of the copolypeptide membrane on the water of pH 4. The leucine zipper in the copolypeptide was suggested to perform as an important basis for nanostructure formation through a hydrophobic interaction. Exploitation of the recognition and specific binding sites in the copolypeptide will allow the self-assembling mechanism of the copolypeptide to be developed to a novel nano-template.