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Biomimetic Synthesis of the Nanocomposite of Phosphorylatd Chitosan and Hydroxyapatite and its Bioactivity In Vitro

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Abstract:

Phosphorylated chitosan (PCS) was used as the template to control hydroxyapatite(HAp) growth, a novel nanocomposite composed of PCS and HAp was synthesized by biomimetic method. Calcium phosphate (Ca 2+= 60mM, Ca/P = 1.67) solution in HCl was added dropwise into PCS solution in NaOH. The precipitate was lyophilized to obtain the composite. The biocompatibility of the PCS-HAp nanocomopite was evaluated by osteoblast culture in vitro. The results showed that low crystallized HAp nanocrystals was formed on the PCS fibers and its crystallographic c-axis were aligned preferentially parallel to the long axis direction of PCS; the composite have good biocompatibility in vitro. It is expected that the novel composite to be a potential material for bone repair.

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Periodical:

Key Engineering Materials (Volumes 330-332)

Pages:

721-724

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.330-332.721

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Online since:

February 2007

Authors:

Quan Li Li, Nan Huang, Zhi Qing Chen, Xu Yan Tang

Keywords:

Biomimetic, Biomineralization, Hydroxyapatite (HAP), Osteoblast, Phosphorylated Chitosan

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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