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Injectable Chitosan Carrier for Demineralized Bone Matrix

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Abstract:

In this study, we developed an injectable carrier for demineralized bone matrix (DBM) which consists of chitosan and glycerol phosphate (GP). The phase transition behaviors of chitosan and GP solution characterized as a function of temperature. The chitosan and GP solutions were shown to form a sol at room temperature, and the chitosan solution with 10-20 wt% concentrations were found to undergo sol-to-gel phase transitions as the temperature was increased. In situ gel forming implant in vivo was successfully fabricated by simple subcutaneous injection of chitosan and GP solutions with demineralized bone matrix (DBM). von Kossa images of the gel implant formed from solution with DBM revealed the presence of mineral deposits.

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Periodical:

Key Engineering Materials (Volumes 342-343)

Pages:

177-180

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.342-343.177

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Online since:

July 2007

Authors:

Yu Han Kim, Mi Hee Cho, In Bum Song, Hoon Hyun, Jung Won Lee, Moon Suk Kim, Seog Jin Seo, Ke Won Kang, Gil Son Khang, Sung Yun Yang, Hai Bang Lee

Keywords:

Carrier, Chitosan (CS), Demineralized Bone Matrix, Injectable Gel

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© 2007 Trans Tech Publications Ltd. All Rights Reserved

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