Preparation and Characterization of Small Intestinal Submucosa Coated with Alginate/Gelatin as a Wound Dressing

Min Suk Lee; In Bum Song; Gil Son Khang; Moon Suk Kim; Hai Bang Lee

doi:10.4028/www.scientific.net/KEM.342-343.69

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Tissue Regeneration of a Hybrid Vascular Graft Composed of Biodegradable Layers and Non-Biodegradable Layer by Static and Pulsatile Flows
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A Novel Method for Porous Chitosan Scaffold
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Preparation and Characterization of Small Intestinal Submucosa Coated with Alginate/Gelatin as a Wound Dressing
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The Biocompatibility of Silk Scaffold for Tissue Engineered Ligaments
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Biodegradable Porous PCL/HA Scaffolds for Bone Tissue Engineering
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Toxicity Test of Wound Covering Material on Animals
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Observation of Proliferation and Attachment of Three Different Cell Types on Nano-Fibrous Silk Film & Scaffold
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HomeKey Engineering MaterialsKey Engineering Materials Vols. 342-343Preparation and Characterization of Small...

Preparation and Characterization of Small Intestinal Submucosa Coated with Alginate/Gelatin as a Wound Dressing

Abstract:

To develop a wound dressing that can be removed from the injured skin without the damage and supporting rapid healing, we made hybrid dressing of small intestinal submucosa (SIS) and hydrogels. Alginate and gelatin used as a dressing material in hydrogels were selected to coat SIS sheets. Characteristics and tendency of wound healing of prepared sheets were investigated. Water uptake ability was greater when the sheets were coated with gelatin than alginate although both showed higher water absorption than the native SIS sheets, but the degradation rate of alginate/gelatin coated SIS was slower than that of native SIS because both polymers may delay contact time of enzyme to the SIS surface in solution. It was observed that less of fibroblasts attached to the natural polymer coated SIS sheets. This property will make easy for the detachment of the sheet from the defected tissue. Wound closure examination showed that prepared sheets enhanced wound healing. It was concluded that prepared alginate/gelatin coated SIS sheets are positively regarded as an appropriate biodegradable wound dressing that is reducing patient’s pain during change of the dressing.