Paper Titles
Bone Regenerative Property of Octacalcium Phosphate in Mouse Critical Sized Calvarial Defects
p.1253
Comparison of New Bone Formation and Osteotomy Speed in the Rabbit Mandible Using Piezoelectric Surgery and Conventional Burs
p.1257
Effect of Synthetic β-TCP and Bovine-Derived Hydroxyapatite Grafting on Bone Regeneration in Rats
p.1261
Hybrid Chitosan Membranes Tested in Sheep for Guided Tissue Regeneration
p.1265
Stimulatory Effect on Osseous Repair of Zinc-Substituted Hydroxyapatite: Histological Study in Rabbit’s Tibia
p.1269
Effect of Hydroxyapatite and Zinc-Containing Hydroxyapatite on Osseous Repair of Critical Size Defect in the Rat Calvaria
p.1273
Improvement of Radio Opacity of Injectable Bone Substitute MBCP GelTM for Minimal Invasive Surgery MIS
p.1277
Hydroxyapatite Ceramic Hip Survey: Ceramic/Ceramic Bearings
p.1283
Ceramic Total Knee Prosthesis with Smooth Surface Keeps High Wear Resistance in Long Clinical Use
p.1287

Stimulatory Effect on Osseous Repair of Zinc-Substituted Hydroxyapatite: Histological Study in Rabbit’s Tibia

Article Preview

Abstract:

The study was carried out aiming the evaluation of the effect of hydroxyapatite (HA) and zinc-substituted hydroxyapatite (ZnHA) on osseous repair of rabbit’s tibia. For the study, 15 adult animals, weighing around 2.5 and 3.0 Kg, sourced by the Fluminense Federal University Animal Lab were acquired. Two perforations were created in each tibia and filled with cylinders (2x6 mm) of HA (group 1, right) or ZnHA (group 2, left). The animals were killed after 7, 14, and 28 days for evaluating the histological aspects of the interface site and bone repair. No sign of inflammatory reaction surrounding the cylinders area were observed, neither giant cells. Osteogenesis was evidently accelerated in all healing periods for the ZnHA group in regards to the HA group. Randomly dispersed areas of neoformed bone among wide areas of fibrous connective tissue was observed in the HA group. We conclude that both biomaterials are biocompatible, but zinc-containg HA enhanced and accelerated the osteogenesis in relation to HA.

You might also be interested in these eBooks
Bioceramics 20 View Preview

Info:

Periodical:

Key Engineering Materials (Volumes 361-363)

Pages:

1269-1272

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.361-363.1269

Citation:

Cite this paper

Online since:

November 2007

Authors:

Monica Calasans-Maia, Antonella M. Rossi, Eliane Pedra Dias, Silvia R. A. Santos, Fabio Áscoli, José Mauro Granjeiro

Keywords:

Bone Repair, Hydroxyapatite (HAP), Light Microscopy, Osteoconduction, Rabbit Tibia, Zinc Containing Hydroxyapatite

Export:

RIS, BibTeX

Price:

Permissions CCC:

Request Permissions

Permissions PLS:

Request Permissions

Сopyright:

© 2008 Trans Tech Publications Ltd. All Rights Reserved

Share:

Citation:

References

[1] A. Uschida, N. Araki, Y. Shinto, H. Yoshikawa, E. Kurisaki, K. Ono. The use of calcium hydroxyapatite ceramic in bone human surgery. J Bone Joint Surg Br. 72: 298-302, (1990).

DOI: 10.1302/0301-620x.72b2.2155908

Google Scholar

[2] A. S. B. Moreira, M. T. Pastoreli, L. H. F. Damasceno, H. L. A. Defin. Estudo experimental da influência das dimensões dos grânulos de hidroxiapatita na integração óssea. Acta Ortop Bras. 11(4): 240-250, (2003).

DOI: 10.1590/s1413-78522003000400007

Google Scholar

[3] A. Ito, K. Ojima, H. Naito, N. Ichinose, T. Tateishi. Preparation, solubility, and cytocompatibility of zinc-releasing calcium phosphate ceramics. J Biomed Mater Res. 50: 178-83, (2000).

DOI: 10.1002/(sici)1097-4636(200005)50:2<178::aid-jbm12>3.0.co;2-5

Google Scholar

[4] M. Yamaguchi, H. Oishi, Y. Suketa. Stimulatory effect of zinc on bone formation in tissue culture. Biochem Pharm, 36(22): 4007-4012, (1987).

DOI: 10.1016/0006-2952(87)90471-0

Google Scholar

[5] T.J. Webster, C. Ergun, R.H. Doremus, R. Bizios. Hydroxyapatite with substituted magnesium , zinc, cadmium, and yatrium II: mechanism of osteoblast adhesion. J Biomed Mater Res. Vol 59: 312-317, (2002).

DOI: 10.1002/jbm.1247

Google Scholar

[6] T.J. Webster, E.A. Massa-Schlueter, J.L. Smith, E.B. Slamovich. Osteoblast response to hydroxyapatite doped with divalent and trivalent cations. Biomaterials. Vol 25: 2111-2121, (2004).

DOI: 10.1016/j.biomaterials.2003.09.001

Google Scholar

[7] A. Ito, H. Kawamura, S. Miyakawa, P. Layrolle, R. Aomori, S. Tsutsumi. Preparation, solubility, and cytoompatibility of zinc-releasing calcium phosphate ceramics. Key Eng Mater. 192- 195, 199-202, (2001).

DOI: 10.4028/www.scientific.net/kem.192-195.199

Google Scholar

[8] J. Brandão-Neto, V. Stefan, B.B. Mendonça, W. Bloise, A. V. B. Castro. The essential role of zinc in growth. Nutrition Research, 15(3): 335-358, 1995. A D B E C F Figure1. Photomicrographies showing the tissue remodeling around HA (A-C) and ZnHA (D-F) cylinders on 7, 14 and 28 days after surgery. Neoformed bone(arrow), connective tissue (�), biomaterial (*), cortical bone (CT). Magnification: 40X.

DOI: 10.1016/0271-5317(95)00003-8

Google Scholar