Paper Titles
Acknowledgements
Preface
Multiphasic Biomaterials: A Concept for Bone Substitutes Developed in the "Pays de la Loire"
The Effect of Reaction Conditions on Hydroxyapatite Particle Morphology and Applications to the Reticulated Foam Method of Scaffold Production
p.3
In Vitro Dissolution Behavior of Custom Made CaP Scaffolds for Bone Tissue Engineering
p.7
Synthesis and Degradation Studies of Novel Calcium Polyphosphates
p.11
Validation of an Analytical Model Describing Mechanical Properties of Porous BCP Ceramics
p.15
The Effect of Slip Loading on the Properties of Porous Calcium Phosphate Bioceramics
p.19
Influence of Ca2P2O7 on Sintering Ability, Mechanical Strength and Degradability of β-Ca3(PO4)2 Bioceramics
p.23

In Vitro Dissolution Behavior of Custom Made CaP Scaffolds for Bone Tissue Engineering

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Abstract:

The degradation rate of custom made calcium phosphate scaffolds, designed for bone tissue engineering applications, influences the healing process of critical size bone defects. An optimal degradation rate exists at which the neo-formed bone replaces the CaP (calcium phosphate) scaffold [1]. Consequently investigating the complex degradation behavior (dissolution, reprecipitation, osteoclast activity) of custom made CaP structures gains interest. In this work different in vitro dissolution experiments were performed to study the degradation behavior of 4 by composition different calcium phosphates. Ideally these experiments should have a predictive power regarding the in vivo degradation behavior. In vitro dissolution tests still lack standardization. Therefore this study focuses on the influence of two dissolution constraints: (i) the material’s macrostructure (porous - dense), (ii) the regenerated fluid flow (bath shaking - perfusion). From 4 different CaP compositions porous structures and as a reference dense disks were produced, using the same starting powder and heat treatment. To compare the different dissolution tests, all data was normalized to the CaP surface area. Results show that besides the structural appearances of the CaP structures, also the design of the dissolution test influences the in vitro dissolution behavior. Moreover there is a need to take the morphology of the dissolved material into account. The CaP perfusion tests show dissolution dynamics that resemble the in vivo reality more closely than the shaking bath experiments.

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Periodical:

Key Engineering Materials (Volumes 361-363)

Pages:

7-10

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.361-363.7

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Online since:

November 2007

Authors:

Saartje Impens, Roosmarijn Schelstraete, Steven Mullens, Ivo Thijs, Jan Luyten, Jan Schrooten

Keywords:

Calcium Phosphate, Dissolution, Hydroxyapatite (HAP), Scaffold, Tricalcium Phosphate

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© 2008 Trans Tech Publications Ltd. All Rights Reserved

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