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Physico-Chemical Properties and Performance of Novel PEEK-WC Membranes Contacting Human Plasma and Proteins

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Abstract:

The aim of this work was the exploration of a potential biocompatible membrane prepared from a modified polyetheretherketone (PEEK-WC). The physico-chemical properties of PEEK-WC were characterised by Differential Scanning Calorimetry and FT-Infrared Spectroscopy. The surface affinity of this membrane to human plasma and proteins such as albumin, fibrinogen and immunoglobulins G was evaluated and compared with that of commercial membranes. The wettability of all investigated membranes was established by water contact angle measurements. PEEK-WC membranes exhibited moderate wettability and low protein adsorption, differently from other commercial membranes such as cellulose acetate membrane. A preferential adsorption of hydrophilic proteins as albumin on the membrane surfaces was observed. Human plasma adsorption on membranes followed the same trend as individual protein solutions.

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Periodical:

Materials Science Forum (Volumes 480-481)

Pages:

257-268

DOI:

https://doi.org/10.4028/www.scientific.net/MSF.480-481.257

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Online since:

March 2005

Authors:

L. De Bartolo, A. Gugliuzza, S. Morelli, B. Cirillo, A. Gordano, Enrico Drioli

Keywords:

Human Plasma, Modified Polyetheretherketone, Polymeric Membranes, Protein Adsorption

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© 2005 Trans Tech Publications Ltd. All Rights Reserved

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