Paper Titles
Nanostructure Properties of Hydroxyapatite Nanobelts Prepared by Oil-in-Water Emulsion
p.187
Preparation of Hydroxyapatite-Fibroin Nanocomposites
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In Vitro and In Vivo Biocompatibility of Nano-Hydroxyapatite/Collagen Composites
p.195
Manufacturing Porous Blocks of Nano-Composite of Needle-Like Hydroxyapatite Crystallites and Chitin for Tissue Engineering
p.199
Preparation of Nano-Hydroxyapatite/Poly(D,L-Lactide) Composite and Its Degradation in Femora of Rabbits
p.203
In Vitro Behaviors of Copolymer of Poly (1,4-Phenylene Sulfide-2, 4-Phenylene Sulfide Acid) and Its Nano Hydroxyapatite Composites
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Preparation of Chitosan/Hydroxyapatite Nanocomposite with Layered Structure via In Situ Compositing
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Preparation of Bioactive Nanophase Titania Ceramics by Alkali-Heat Treatment
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Electrochemical Preparation of Ordered Nano HAp Coatings on Ti Substrate and In Vitro Study on Its Bioactivity
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Preparation of Nano-Hydroxyapatite/Poly(D,L-Lactide) Composite and Its Degradation in Femora of Rabbits

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Abstract:

With the outstanding biocompatibility of hydroxyapatite (HA) and biodegradation of poly(D,L)lactide(PDLLA), and the expected good bio-mechanical compatibility, nano-HA / PDLLA (n-HA/PDLLA)composite has been paid great interests in hard tissue repair. One of the key factors affecting the potential of the composite is the degradation of the composite. That is what the mechanism of degradation in the composite is and if the degradation of the materials would induce the crack of the composite or a porous structure facile for tissue ingrowth would be formed. In this study, an n-HA/ PDLLA composite containing about 40% n-HA (wt%) was prepared and the degradation of the composite in bony tissue of rabbits and tissue response were studied by implanting composite rods and control HA rods into the femora of 16 New Zealand rabbits. After definite intervals, the histological analysis was completed by light microscopy and the degradation behavior was observed by scanning electron microscopy. The results suggested that a nano-HA/PDLLA composite was obtained and the materials showed good biocompatibility and osteoconductivity. The substantial degradation of the composite occurred at 8 weeks in vivo. After a longer period of implantation, the further degradation of the composite led to the formation of interconnected microporous and macroporous structure in the materials that might facilitate the tissue ingrowth in the composite.

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Periodical:

Key Engineering Materials (Volumes 288-289)

Pages:

203-206

DOI:

https://doi.org/10.4028/www.scientific.net/KEM.288-289.203

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Online since:

June 2005

Authors:

Yu Mei Xiao, Hong Song Fan, Xin Long Wang, Jin Rui Xu, Jing Qiu Cheng, Xu Dong Li, Xing Dong Zhang

Keywords:

Hydroxyapatite (HAP), Nanocomposite, Poly(D,L-Lactide) (PDLLA)

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© 2005 Trans Tech Publications Ltd. All Rights Reserved

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