This study investigated the model and simulation of dynamic cutting forces for high speed end mills, performed frequency spectrum analysis of dynamic cutting forces, and propounded the model and failure criterion of high speed end mills with indexable inserts. According to results of modal analysis and stress field analysis, the safety prediction and experiment of high speed end mills for machining aluminum alloy were done. Results indicate that more teeth of cutter and greater cutting contact angle make the energy more dispersible, higher cutting speed and greater rake of cutter can depress dynamic cutting forces. The rigidity failure rotational speed is higher the strength failure rotational speed, the connection strength between cutter body and screw bolt affects directly the safety of cutter. The model of high speed end mills based on spectrum simulation for dynamic cutting forces, and the safety prediction based on finite element analysis should be applied to the development of high speed end mills as an effective means.