By the combination of orthogonal experiments and moldflow simulation analysis, the warpage of a thin-wall injection molded parts is analyzed under the combined effects of multi-molding process parameters. By this method, it can gain the experiment data which can basically reflect the overall situation using fewer number of simulation analysis. In addition, the effects degree of different molding process parameters for warpage are researched, and the optimized parameter combination is obtained. It can avoid the one-sidedness of individual analysis of the various factors and solve the unreasonable appearance of process parameter settings. With the help of results, it can fasten the mold developing schedule, thus shorten the cycle of product development, and improve the quality of products and the competitive ability of enterprise.