Taking Yangjiawuchang Bridge 2 Slope Project on the national key high line of Hangzhou to Lanzhou in China as example, the deformation characteristics of typical profile 4-4’ of the deposits highway slope project was studied by means of numerical simulation (FLAC3D). Based on the deformation fields, the slope deformation features were analyzed. According to the slope coefficient that was solved by strength reduction method, the slope stability was evaluated. In consideration of numerical simulation results and field geological conditions, the combination engineering treatments of surface drainage, paring-earthwork and unloading and slope temporary protection were selected. Moreover, the paring-earthwork areas were calculated and optimized. The simulation results can be based on to guide the engineering treatment, meanwhile, the results can provide reference for the similar engineering.