AZ80 magnesium alloy was semi-continuously cast under different physical fields which were conventional direct chill (DC) casting, low frequency electromagnetic casting (LFEC), ultrasonic casting (USC) and electromagnetic-ultrasonic combined casting (ECUC), respectively. The effect of different physical fields on solidification structures of AZ80 alloys was investigated. The results show that compared with the conventional DC casting, structures of AZ80 alloys billets cast with LFEC and USC have been greatly refined. The effective refinement takes place in the edge of billets when LFEC is applied. However, the effective refinement takes place in the center of billets when USC is applied. When combination of low frequency electromagnetic and ultrasonic fields is applied during semi-continuous casting AZ80 magnesium alloy billet, structures of AZ80 alloys are refined significantly in the whole billets everywhere and more uniform.