Paper Title:
Simultaneous Determination of 10-Deacetylbaccatin,Cephalomannine and Taxol in Different Parts of Taxus Media with Different Growth Years by UPLC
  Abstract

Taxus media is the natural hybrid variety of Taxus cuspidate and Taxus baccata, and has been used as an anticancer plant with some medical components-taxanes. In this study, ultra performance liquid chromatography was used for quantification of three major bioactive taxanes in Taxus media, which were collected in Zhejiang province and Sichuan province (China). As a result of this study, a convenient, accurate, rapid and reproducible UPLC method has been developed to successfully quantify 10-Deacetylbaccatin Ⅲ (10-DABⅢ), Cephalomannine and Taxol in the needle and twig of Taxus media. The results indicate that the sequence of the contents of three active components in Taxus media with different parts was needle>twig; the sequence of the contents of three active components in Taxus media with different growth years was 5 year old >4 year old >3 year old; and there were great differences in the contents of three active components in Taxus media between Zhejiang province and Sichuan province. The results also provided a scientific basis for uses of Taxus media.

  Info
Periodical
Chapter
Chapter 2:Materials Science and Bioengineering
Edited by
Barry Tan
Pages
326-330
DOI
10.4028/www.scientific.net/AMM.108.326
Citation
J. Zhang, C. F. Yang, K. Yuan, "Simultaneous Determination of 10-Deacetylbaccatin,Cephalomannine and Taxol in Different Parts of Taxus Media with Different Growth Years by UPLC", Applied Mechanics and Materials, Vol. 108, pp. 326-330, 2012
Online since
October 2011
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Lin Zhao, Ji Lin Dai, Jia Yi Wang, Ya Wei Li, Xin Li Liu
Session 3: Biology-Related Materials Research in Environmental Protection
Abstract:Epothilones are a kind of poliketide macrolide with antifungal and anticancer bioactivity which are attracting more and more attention. In...
958
Authors: Hai Yan Wu, Xin Ping Liu
Chapter 10: Biomaterials, Low Carbon and Environmental Protection
Abstract:Chemical semi-syntheticmethod for efficient low toxicity of paclitaxelanalogues is the hot issue quite a longtime in the present and the...
1055
Authors: Xiao Gong, Xiao Bing Huang, Yong Hua Wei, Ning Li Qi, Li Jing Lin, Yang Yang Liu
Chapter 3: Bio- and Medicine Research
Abstract:A simple and sensitive ultra-performance convergence chromatography system coupled with a diode array detector for analysis of paclitaxel,...
1060