Anisotropic hydrogels based on acrylamide were prepared by frontal photopolymerization. First hydrophilic microgels (HM) were spreparaed by inverse emulsion photopolymerization, and secondly hydrophilic reactive microgels (HRM) with C=C double bonds were synthesis by chemical modification of the HM used N-methylolacrylamide, Last, HRM hydrogels were synthesis by frontal photopolymerization using HRM as crosslinkers. Only one direction of the HRM hydrogels show excellent fracture strength and tensile elongation but the other two directions show little fracture strength and tensile elongation. The reason of the high mechanical performance in the given direction is that the hydrogels are crosslinked by HRM as a new crosslinking agent instead of the conventional crosslinking agents and these nanoparticles can self-assemble into anisotropic structures and the structure can be stabilized by free radical polymerization. The anisotropic hydrogels could use potential materials such as artificial muscles tissue.