TiO2 nanotube was prepared by anodization method. CuO and WO3 were loaded by wet impregnation method. The microstructure, phase characteristic and photoelectrocatalytic hydrogen generation performance were studied. The annealed samples were soaked in a mixture solution containing tungstic acid and Cu (NO3)2 and then post-annealed to fabricate Cu-loaded TiO2 nanotube. The obtained samples were characterized by SEM, EDX, XRD and the photoelectrocatalytic hydrogen generation under UV illumination was measured and compared.