Paper Title:
Facile Synthesis of N-{2-[4-(2-Pyrimidinyl)-1-Piperazinyl]ethyl} Adamantane-1-Carboxamide
  Abstract

A facile method for the synthesis of N-{2-[4-(2-pyrimidinyl)-1-piperazinyl]ethyl} adamantane-1-carboxamide(Adatanserin) was developed by using 2-chloropyrimidine and adamantanecarbonyl chloride as the starting material via amidation and N-alkylation, using convergent route to reduce workups and steps in a good yield. The structures of compounds were confirmed by IR spectral, 1HNMR and elemental analyses.

  Info
Periodical
Chapter
Chapter 7: Functional Materials
Edited by
Huixuan Zhang, Ye Han, Fuxiao Chen and Jiuba Wen
Pages
1319-1322
DOI
10.4028/www.scientific.net/AMM.117-119.1319
Citation
Q. Su, J. W. Guo, C. F. Yang, Y. D. Cui, "Facile Synthesis of N-{2-[4-(2-Pyrimidinyl)-1-Piperazinyl]ethyl} Adamantane-1-Carboxamide", Applied Mechanics and Materials, Vols. 117-119, pp. 1319-1322, 2012
Online since
October 2011
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$32.00
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