The ball defects generated in skew rolling process have restricted to large extent the further application of skew rolling technology in ball manufacturing industry. Research was carried out so as to find the factors and laws of influencing on skew rolling ball quality. It was found by analyzing the forces exerting on the ball that the deforming velocity of ball had the largest influence on the resistance to deformation. Simulations were done respectively under different roller obliquities, different distances between two guide plates, and different rotation speeds of rollers by means of DEFORM-3D software. Finally, the influencing factors and laws on ball quality were discovered.