This paper describes the hydrodynamic performance prediction of ship hull with propeller by using CFD techniques. As an attempt in investigating the flow features around ship hull equipped with a rotating propeller, open water test, resistance test, and self-propulsion test were conducted. The paper discusses also the applicability of different turbulence models which are used to predict the hydrodynamic performance of the propeller, the hull, and the interaction hull-propeller. The hydrodynamic performance prediction method was gotten and was validated. The computational results were validated against the existing experimental data.