Titanium is a class of material difficult to common machine. Laser processing is a feasible method for machining of titanium. This paper presents cutting investigation of industry pure titanium sheet with conventional laser and water-jet guided laser, and analyses their processing features by means of the surface morphology of kerf obtained from Scanning Electron Microscope. The result shows that the machining quality and cleanliness of water-jet guided laser processing is much better than conventional laser processing. The impact and cool effects of the high-speeds water jet are more effective to trim the cut surface and remove molten waster.