Based on Multi-body system Dynamic theory, front suspension model is established by using ADAMS/Car, and then the validation is finished according to suspension K&C test project. Through the model simulation, the sensitivity of structure parameters to suspension kinematics characteristics has been analyzed and then the most sensnetive ones have been sorted out. The suspension structure geometry parameters are optimized by the application of DOE method based on virtual prototype technology. The parallel travel simulation results are as follows: the values of camber angle, toe angle, kingpin inclination angle, steer angle and lift/dive are reduced, and the values of caster angle are increased slightly with the optimized suspension. Consequently, the optimized suspension is more conducive to vehicle handling stability compared with the original one. This optimization design method provides the technical support for suspension positive development.