Mo-based composites with Al2O3 particles were developed in order to enhance the wear resistance of molybdenum alloys. Using Al2O3 power and pure Mo power as raw materials, the Molybdenum powders mixed with Al2O3 particles were prepared using planetary ball mill. And then the Mo-based composites with 3-10vol.% Alumina were prepared by compaction and sintering at 1840°C. The morphology of the Molybdenum powder and microstructure of the composites were analyzed by SEM and XRD. The micro-hardness, density and wear property of composites were researched. The results show that the microstructure of composites is composed of α-Al2O3 particles and Molybdenum matrix. With the increase of Alumina content, the microhardness of Molybdenum matrix increases, and the density first increases and then decreases. The friction coefficient of composite is scarcely affected by the alumina content. While the wear resistance of the composites rises with the increase of Alumina content. The wear failure is caused by abrasive wear characterized by obvious plow furrow and abrasive dust on the worn surface.