The high-speed milling process has been widely used for manufacturing the aeronautical aluminum alloys. And it is quite important to choose the logical milling parameters for improving the precision and surface quality in the high-speed milling aluminum alloys. In this paper, the orthogonal experiments are designed and made to construct the relationships between the milling force and milling factors to 7050-T7541 aluminum alloys. The milling factors are mainly consist of the milling speed, the feed rate, the milling depth and the milling width. The empirical formulas of milling force are derived by multiple linear regression analysis, and the formulas are tested to be correct by the single factor experiment. The research is very important for further study of the aluminum alloys.