Paper Title:
Study on Preparation and Property of Drug Loading of AZM-PCL Nanoparticels
  Abstract

This study was to prepare polycaprolactone (PCL) nanoparticles. The biodegradable PCL was used as the carrier, and Azithromycin (AZM) was used as the model drug. AZM-PCL nanoparticles (AZM-PCL-NPS) were prepared by desolvation method. The effect of preparation condition: concentration of PCL, molecular weight of PCL, organic solvents, dosage ratio and so on, were specially noted and compared. A homogeneous size distribution and good dispersion were observed, the average diameter was around 70~400 nm, and the distribution index was 0.036~0.136. The drug loading reached 27.69 %, and the efficiency of encapsulation reached as high as 93.25%. The results were better than the other similar researches, this preparation way was successful.

  Info
Periodical
Chapter
Chapter 3: Advanced Manufacturing Technology (2)
Edited by
Dongye Sun, Wen-Pei Sung and Ran Chen
Pages
1764-1768
DOI
10.4028/www.scientific.net/AMM.121-126.1764
Citation
L. L. Ruan, D. X. Wang, Y. W. Zhang, J. X. Zhao, M. W. Wang, X. F. Zhang, N. L. Chen, "Study on Preparation and Property of Drug Loading of AZM-PCL Nanoparticels", Applied Mechanics and Materials, Vols. 121-126, pp. 1764-1768, 2012
Online since
October 2011
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Price
$32.00
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