This paper presents an experimental study on the energy saving effect of building envelope in winter in Chongqing city. The basic cubicle was adopted for comparison. Experiments show that when energy saving measurements are applied in the external walls and windows, energy saving cubicle has an average energy efficiency rate of 32.68%, 7.68% over the target value of the standard. The indoor temperature of the energy saving cubicle is higher than the basic one’s. The internal surface temperature and the temperature difference between the exterior and interior of the insulation wall of the energy saving cubicle are both higher than that of the basic cubicle, the mean value is 1.28°C and 1.90°C respectively. And the temperature difference of the insulation glass is higher than that of the single glass, with a maximum value of 6.32°C. Daily simulation of the two cubicles is addressed by VisualDOE-4.0, the mean error between simulation and experiment is 16.16%, illustrating the effectivity and the accurateness of the VisualDOE-4.0.