Paper Title:
Freeze Drying Technology Forming Drug Release Bionic Scaffolds with Gradient Structure
  Abstract

A kind of drug release bionic scaffold with gradient structure was designed to release drugs. The scaffold mould had been designed with CAD software and fabricated with rapid prototype. The bionic beta-tricalcium phosphate (β-TCP) scaffold was fabricated with freeze drying. It was composed of two coaxial cylindrical porous scaffolds. The internal loose scaffold was embedded in the outer dense layer. The two different density layers of the scaffold could be used to adjust the drug releasing rate through regulating the slurry concentration. The scaffold was distributed with pores ranged from 30μm to 100μm. The research indicated that the scaffold with gradient structure could be loaded with two kinds of drugs which were released at different rate. The scaffolds were fit as the substitute materials for bone repairing.

  Info
Periodical
Chapter
Chapter 7: Computer Application in Design and Manufacturing (1)
Edited by
Dongye Sun, Wen-Pei Sung and Ran Chen
Pages
3935-3939
DOI
10.4028/www.scientific.net/AMM.121-126.3935
Citation
L. L. Lin, L. P. Zhou, Z. K. Wang, Q. X. Hu, M. L. Fang, "Freeze Drying Technology Forming Drug Release Bionic Scaffolds with Gradient Structure", Applied Mechanics and Materials, Vols. 121-126, pp. 3935-3939, 2012
Online since
October 2011
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Price
$32.00
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