The Human Machine Interface (HMI) of Monitor& Control System (MCS) is an important part of main control room in Nuclear Power Plants (NPP). The MCS is integrated by networks, digital computers and computer software. The paper discusses a new design mode for the HMI of MCS in Nuclear Power Plants. How to make the MCS information available is the focus of the HMI research. The paper discusses the design and research about the main layout and functions of the HMI. In order to verify and validate the design of HMI, the HMI of MCS is developed by a configuration software of JADE. HMI debugged with the NPP simulator. The Test illustrates that the HMI can help the operators to get very important information from MCS, which help the operators to operate the nuclear plant safely and reduces the human error.