Aiming at the quality management issues in manufacturing enterprise, this paper establishes the product lifecycle quality management (PLQM) system based on the architecture of SOA and the knowledge of computer integrated manufacturing. This assembly-centered PLQM system collects and analyzes the quality data by integrating different information systems. The system-crossing quality management process, and the mechanism of problem prevention are also included in this system to realize the quality problem tracing and run-to-zero quickly. Therefore, this PLQM system provides the decision making supports for the quality plan, quality inspection and quality analysis in the product's whole quality management process. These measures help guarantee the quality of the final product effectively.