20CrMnTi steel is usually employed in the fabrication of wearable parts subjected to medium dynamic load, such as change gear, gear shaft, cross pin end, etc., which are extensively adopted in the automobile industry. The stability of hardness ability and strength ability of 20CrMnTi steel are important performance in producing gear steel. For the sake of researching the effect of austenitizing temperature and holding time on the quenching hardness and tensile strength, the central composite design, response surface method and multi-objective optimization are carried out to optimize the operating variables viz. austenitizing temperature and holding time. The results indicate that the optimum conditions are austenitizing temperature of 910.54°C and holding time is 0 min. Meanwhile, the predicted values of quenching hardness and tensile strength are not less than 49.19 HRC and 1444.29 MPa.