Operational simulator is a simulated training system used in a flight control center to train and improve mission operators’ ability to control and track spacecrafts, constructing a realistic mission-like circumstance for the system drilling. But previous simulator had not a centralized monitor. It must be operated and monitored at different terminals. Usually several operators are required to operate at the same time with a demanded order. It is very inconvenient to use. So, the centralized monitor software is specially designed for Chang’E-1 operational simulator. It is used for operations, status setting, Data management and monitors of the simulator. This paper introduces functional requirements, network structure, and design scheme of modules of the software. The object-oriented programming of plug-ins is adopted in the program development. The practice proves that it is very convenient for a single user to operate the Chang’E-1 operational simulator by using the centralized monitor software, and it also saves manpower and cut expense. The software architecture can be applied in centralized monitor software of future simulators.