Intelligent control methods of missile guidance and control system (GACS) are studied in this paper. Secondly, the component and principle of GACS is introduced. Based on the fuzzy neural network, this paper constructs a basic structure of the intelligent control method of missile. Meanwhile, a new intelligent control method of rolling channel of missile based on Fuzzy Cerebella Model Articulation Controller (FCMAC) is designed. Under complicated environmental conditions, the missile can be accurately controlled with this method. Finally, the application value is illustrated. It’s very meaningful to improve the combat capability.