Paper Title:
Colon-Targeted Drug Delivery Microparticles Prepared Using Electrohydrodynamic Atomization
  Abstract

Electrohydrodynamic atomization (EHDA) process was exploited to prepare drug-loaded microparticles for colon-targeted drug delivery. Field emission scanning electron microscope results showed that the particles had a size of 1.3±0.7 μm. Differential scanning calorimetry (DSC) analyses and wide-angle X-ray diffraction analyses (XRD) results similarly demonstrated that the drug DS had been totally converted into an amorphous state in the EHDA microparticles with Eudragit® L-100 as the polymer matrix. Attenuated total reflectance Fourier transform infrared analysis disclosed that the secondary interactions presented between DS and Eudragit® L100 molecules. In vitro dissolution tests verified that the microparticles had a pH-dependent and sustained drug release profile. The present study provides an easy way for developing colon-targeted drug delivery microparticles.

  Info
Periodical
Edited by
Han Zhao
Pages
1663-1667
DOI
10.4028/www.scientific.net/AMM.130-134.1663
Citation
D. G. Yu, X. Wang, P. Lu, X. Chen, H. P. Zhao, X. Y. Li, W. Qian, Y. Li, Y. Z. Liao, "Colon-Targeted Drug Delivery Microparticles Prepared Using Electrohydrodynamic Atomization", Applied Mechanics and Materials, Vols. 130-134, pp. 1663-1667, 2012
Online since
October 2011
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$32.00
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