The experiment on gas jet flame extinguishing with water mist in open space was conducted in this paper. On the basis of experimental result, the process of the flame extinguishment can be classified into two categories:1) when fuel flow rate is small, the gas jet flame can be suppressed and extinguished quickly; 2) When fuel flow is large, the flame lifts from the attached position at the burner exit after suppressed by the water mist. FLUENT is used to simulate the interaction of water mist with gas jet flame. The Eddy-dissipation model (EDM) is used for combustion of flame. the water mist is simulated by Discrete Phase Model (DPM).The simulated results agree well with the experimental results. To some extent, EDM is suitable for simulating the interaction of water mist with a turbulent gas jet flame.