How to find the solution of multi-objective optimization quickly and exactly is the challenge of multi-objective optimization design. This paper explores the feasibility of multi-objective optimization solution briefly in theory, and makes a high-speed train’s anti-creeper as an example which using multi-objective design optimization software to find the feasible solution. Nastran and LS-Dyna are respectively adopted to solve the linear static and collision study analysis of the anti-creeper. In this paper Nastran and LS-Dyna are integrated on Optimus which is MDO platform to make a MDO of anti-creeper. The anti-creeper optimization analysis is proceeded based on many indexes satisfied, and its multi-objective Pareto solution of its minimum mass and biggest internal energy comes out. The method of multi-objective optimization solution in this paper is solved well in MDO.