Axial force is one of the main factors which affect the pump safety and reliability during the operation of pumps, especially in multi-stage centrifugal pumps. 150QJ20 type deep-well centrifugal pump (DCP) is selected as an example to research the pump performance and axial force with the numerical simulation and experiment method. The numerical simulation results were compared with experimental measurements, and such result was analyzed. The results show that the change trend of the pump performance and axial force acquired by numerical and experiment is similar. At rated operating point, the error of axial force between the numerical simulation and experimental measurements is less than 3%. This confirmed the feasibility of predict the pump performance by numerical simulation method.