Hydroxyapatite (HA) is a calcium phosphate ceramics and HA coating is essential for the medical metallic implants. This paper presents a computational model of HA particle impact behavior in cold spraying. The impact pressure at the predefined contact surface between the HA particle and the Ti substrate is investigated numerically using ABAQUS/Explicit. The effects of particle size, particle velocity and substrate temperature on the impact pressure are examined. A Taguchi’s orthogonal array is employed to arrange the simulation conditions and the simulation results are analyzed to reveal the main factors influencing the impact pressure, which provides a better understanding of the bonding mechanism during cold spraying.