Image scrambling is an important technique in digital image encryption and digital image watermarking. This paper proposes a new image scrambling method, which based on chaotic sequence and space-bit-plane operation (SBPO). First, every eight pixels from different areas of image were selected according to chaotic sequence, and grouped together to form a collection. Second, the SBPO was performed in every collection and built eight pixels of the image with new values. The scrambling image was generated when all pixels were processed. This method can scramble image not only based on the pixel’s position but also the value and their corresponding probability. The experimental results show that this scrambling method possesses perfect confusion properties and it can resist various attacks.