MATLAB is a powerful tool for data processing. This paper focused on how to enhance the efficiency of scientific computation in seismic data processing by improving the traditional MATLAB programming code. Some examples were presented to demonstrate the advantage of vector addressing over the traditional scalar addressing. Vector addressing programming can simplify the code significantly, and can it also improve the compiling efficiency and executing efficiency of the code. The other examples were given to illustrate the use of the colon and some special values that can improve the MATLAB programming efficiency. Some issues in this paper can also serve as guidelines for professionals in other disciplines.