To efficiently reduce vibration and noise of a plate, an optimization of passive constrained layer damping (CLD) is presented. The dynamic equation of a sandwich plate with CLD treatment is derived using Lagrange’s method. The assumed modes method is employed to solve the equation and obtain the vibrational energy and sound power, which are used as the objective of optimal design. A genetic algorithm of big mutation is employed to search for the optimum of the location of CLD treatment, the thicknesses of both the constraining layer and the viscoelastic layer and the shear modulus of the viscoelastic material with the restriction of added mass of the total CLD treatment. Numerical results show that for a simply-supported plate with a transverse force (1Hz~200Hz) applied at (0.8La, 0.8Lb), the optimized CLD significantly reduce the vibrational energy and sound power.