Deeply studying vibration and seismic response characteristics of Beijing Yin-tai Center provided information reflecting its anti-seismic performance based on which seismic response observation array was to be deployed. Time-historic analytical methods on the basis of modal analysis were applied to carry out structural seismic response. Two load cases were mentioned including the responses under minor earthquakes and moderate earthquakes. El-Centro wave, Northridge wave and synthetized time-histories were adopted with contrast analysis under Beijing Hotel time-history recorded in Tangshan Earthquake. Peak inter-story shift ratios and peak accelerations are obtained and analyzed. The inter-story shift ratio determines elastic state of structure under minor earthquakes and elastic-plastic state under moderate earthquakes. Predominant inter-story displacement and acceleration response provides the floors with more remarkable seismic response, which are vulnerable floors for monitoring in earthquakes.