Objective: To explore the feasibility and clinical value to keep the denatured dermis in the deep II degree burns. Methods: With the consent of the 41 patients, their burn wounds were divided into two groups, one group is called the observation group, and the other is called the control group. Comparison was made in the same body. Apply retaining denatured dermis plus autograft skin in the observation group and scab removing plus autograft skin in the control group, individually. Then compare the following factors of the two groups: blood loss amount, 14th day wound healing rate, and the color B-measurement of the thickness from the skin surface to fascia thickness. Results: The blood loss was 10.2 ± 2.3 ml in the observation group, 39.2 ± 6.1 ml in the control group. t = - 22.3, P = 0.000; 14d wound healing rate was 75.6% (31/41) in the observation group, and 87.8% (36/41) in the control group. 2= 0.581; P > 0.05. The thickness of skin and subcutaneous tissue was measured to be 1.2 ± 0.5cm in the observation group, and 0.8 ± 0.3cm in the control group, t = 19.4, P = 0.000. Conclusions Retain denatured dermis and implant autograft skin surgery can reduce the intensity of operation, it can also benefit the skin and soft tissue reconstruction. Thus, it is one of the most effective surgical methods in the treatment of deep II degree burns.