Human Herpes Virus 6 (HHV-6), which is different with Human Immunoddficiency Virus (HIV) was first isolated from peripheral blood mononuclearcells of six patients with AIDS and lymphoproliferative disorders in 1986. It is one of the most common viral infection in AIDS patients. The pathological changes caused by HHV-6 are usually serious and easy to recur. The infection affect prognosis of AIDS apparently. HHV-6 infection is related to various diseases, such as chronic fatigue syndrome, necrotizing lymphadenitis, mononucleosis-like syndromes, AIDS, recipients of organ transplantation and hepatitis. HHV-6 can be found even in healthy bodies. At present, little is known about the mechanism of latency and reactivation of HHV-6 so there is no effective specificity drug on HHV-6 infection. Therefore, it is very important to find safety and effective anti-HHV6 drugs. To study the anti-HHV-6 action of Baicalin, the human T-cell strain was used to do the anti-HHV-6 effect in vitro. The result shows that Baicalin has evident effect on cytopathic effect (CPE) caused by HHV-6 GS. This result prompts that Baicalin has therapeutical effect on infection caused by HHV-6t.