Paper Title:

Synthesis and Characterization of an Alendronate-Chitosan Conjugate

Periodical Applied Mechanics and Materials (Volume 140)
Main Theme Medical Materials and Engineering
Edited by Robert Zhu
Pages 53-57
DOI 10.4028/www.scientific.net/AMM.140.53
Citation Xiao Hong Shao et al., 2011, Applied Mechanics and Materials, 140, 53
Online since November, 2011
Authors Xiao Hong Shao, Ji Qing Xu, Yan Peng Jiao, Chang Ren Zhou
Keywords Alendronate, Chitosan (CS), Polymer-Drug Conjugates
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Abstract

The biomineral-binding alendronate-chitosan conjugate (Scheme 1) was developed as a novel drug delivery system. Alendronate was conjugated to the hydroxyl groups of chitosan, thereby maintaining the amino groups of chitosan intact. By means of FT-IR and 1H NMR, the characterization was conducted to confirm the successful synthesis of alendronate-chitosan conjugate.