Synthesis and Characterization of an Alendronate-Chitosan Conjugate
| Periodical | Applied Mechanics and Materials (Volume 140) |
|---|---|
| Main Theme | Medical Materials and Engineering |
| Edited by | Robert Zhu |
| Pages | 53-57 |
| DOI | 10.4028/www.scientific.net/AMM.140.53 |
| Citation | Xiao Hong Shao et al., 2011, Applied Mechanics and Materials, 140, 53 |
| Online since | November, 2011 |
| Authors | Xiao Hong Shao, Ji Qing Xu, Yan Peng Jiao, Chang Ren Zhou |
| Keywords | Alendronate, Chitosan (CS), Polymer-Drug Conjugates |
| Price | US$ 28,- |
The biomineral-binding alendronate-chitosan conjugate (Scheme 1) was developed as a novel drug delivery system. Alendronate was conjugated to the hydroxyl groups of chitosan, thereby maintaining the amino groups of chitosan intact. By means of FT-IR and 1H NMR, the characterization was conducted to confirm the successful synthesis of alendronate-chitosan conjugate.