Paper Title:
Surface Modified Polylactic Acid Microspheres Reinforced Calcium Alginate Hydrogels
  Abstract

Calcium alginate hydrogels, offering cells with three dimensional growing environments similar to that experienced in vivo, is an appealing materials utilized as scaffolds in tissue engineering. However, how to improve its mechanical property and expand its use is becoming an urgent topic that draws great attention. In this paper, we introduced polylactic acid (PLLA) microspheres, treated by surface aminolysis, into calcium alginate hydrogels that was fabricated by the methodology of in-situ release and transformation. The surface aminolysis modification improved the hydrophilicity of PLLA microspheres, which increased the integration between PLLA microspheres and calcium alginate hydrogels. Within the composite hydrogels, PLLA microspheres can play the role of hindrance for the extension of cracks and improve its mechanical strength. Meanwhile, PLLA microspheres can also be used as hydrophobic drugs delivery vehicles to transport gene, protein, peptide and the like. In this way, with the enhancement of mechanical strength and newly given functions, the fields in which the composite hydrogels can be applied can be broadened significantly.

  Info
Periodical
Edited by
Robert Zhu
Pages
58-62
DOI
10.4028/www.scientific.net/AMM.140.58
Citation
L. Li, L. Lu, C. R. Zhou, Z. C. Xu, "Surface Modified Polylactic Acid Microspheres Reinforced Calcium Alginate Hydrogels", Applied Mechanics and Materials, Vol. 140, pp. 58-62, 2012
Online since
November 2011
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Nan Xing, Feng Tian, Jian Yang, Yu Kun Li
Chapter 3: Material Engineering and Science
Abstract:The aim of this study is to prepare and characterize an alginate-chitosan hydrogel for wound dressing application. The influence of alginate...
3396
Authors: Shi Jun Wei, Meng Zhang, Lei Li, Lu Lu
Chapter 8: Composites, Polymers and Biomaterials
Abstract:Multi-membrane hydrogels are newly promising carriers in biomedical fields for their gentle gel condition and excellent biocompatibilities....
1632
Authors: Ya Nan Zhang, Yuan Yuan Liu, Yu Li, Shuai Li, Qing Xi Hu
Chapter 7: Bioresearch and Biomedical Engineering
Abstract:The clinical applications of tissue engineering are still limited by the lack of a functional vascular supply in tissue-engineered...
1290
Authors: Xiao Bing Luo, Ming Feng Ma, Xian Ju Zhou
Chapter 6: Functional Materials for Biomedical Engineering and Biotechnologies
Abstract:The double-layered PVA/nanohydroxyapatite (nHA)-poly (vinyl alcohol)(PVA)-sodium alginate (SA) porous composite scaffolds used as synthetic...
1155