CNC grinder is considered as the key equipment of camshaft production line. Its reliability directly influences the quality of the products. This article takes an analysis of fault record of 15 sets of CNC grinders of production line, gets failure positions analysis, and then reaches data of failure modes, fault reason of CNC grinder. Comprehensive analyses of criticality for the machine are done through establishing models. Therefore, this analysis provides technical basis for repair, maintenance and update of CNC grinder of camshaft production line.