The use of grid manufacturing system, has become the trend of modern manufacturing technology. With reference to the idea of component design for workshop production business, a workflow and multi-agent based Grid of Reconfigurable of Manufacturing Execution System (GRMES) is presented. The configurable workshop production business can be handled, and the MES application system can correspondingly adjust with its change. The KQML is expanded to compensate for its description ability in the Workflow management system. XML is applied to support the data flow in GRMES, format the dispatched tasks and KQML, which can securely and concisely transfer different data among the workflow engines, agents and application on the GRMES. GRMES improves the problems such as adaptability and reconstructivity, which exist in the traditional MES.