Laser ultrasonics opened possibilities to measure thermal and mechanical property of skin which occupies an essential position and is beneficial in industrial and medical applications. This paper focuses on the thermal effect in the thermal section of the laser ultrasonic technique. A transient thermal analysis is developed and promoted to simulate the interaction between the laser pulse and human skin, using a multilayered ﬁnite element model (FEM). Chicken leg had been used and irradiated by KrF laser, the thermal reactions were detected and recorded by a thermal camera. By comparison, the thermal result of experiments and simulation matches.