Mainly based on Singapore’s workplace safety and health (construction) regulations 2007 and China’s safety management measures for section(subsection) works with major hazards 2009, the paper introduces and analyzes the Singapore’s safety management system for high-risk construction works, and simply compares it with the management mechanism of China’s section(subsection) works with major hazards, the following conclusions are drawn: (1) The application scopes of Singapore’s high-risk construction work permit-to-work system and China’s the management mechanism of section(subsection) works with major hazards are different, and generally speaking, the former includes more construction works than the latter. (2) The mechanisms of Singapore’s high-risk construction work permit-to-work and China’s management of section/ subsection works with major hazards are different. (3) In Singapore no independent construction safety supervision system exists, while in China it is usually required by the laws. (4) In Singapore any person who contravenes any provision of workplace safety and health (construction) regulations 2007 which imposes a duty on him shall be guilty of an offence and may be liable on conviction to imprisonment for a term not exceeding 2 years; in China any person who contravenes any provision of safety production law, building law and corresponding safety regulations but doesn’t lead to serious consequences shall not be liable on conviction to imprisonment. (5) In Singapore the safety assessor evaluating and endorsing the application for a permit-to-work must assume his lawful duty for his undue conducts and decisions, in China the safety experts responsible for checking the special safety construction scheme needn’t assume any lawful duty.