Against the hybrid vibration isolation system process design problems, we proposed a hybrid optimization design method for vibration isolation system. Firstly, through investigating the rated operating characteristics of mechanical devices, we summarized the isolation devices effectiveness in the working band as an optimizing objective excitation function and extracted the multi-island algorithm advantage in multi-objective optimization field. Then using iSIGHT and Matlab to implement joint optimization, we got the optimal solution set of the passive vibration isolation parameters. Finally, we realized the system multi-objective control by the optimal control method, and achieved a better vibration isolation performance. This method puts forward a new idea for the succeeding hybrid vibration isolation system design effort.