In this paper, we proposed a new approach to simulate the deformation of skeletal muscles based on bio-mechanical considerations. The musculo-tendon unit, which generates the active and passive force of the muscles to drive skeletal motion, is established according to the tension-length curve. Muscular deformation is achieved by embedding a musculo-tendon unit in the volume-preserving B-spline solid. The model provides suitable visual effect and manages the deformation of muscles on the basis of the bio-mechanical properties. We demonstrated the simulation by creating a musculoskeletal model of the upper limb.This document explains and demonstrates how to prepare your camera-ready manuscript for Trans Tech Publications. The best is to read these instructions and follow the outline of this text. The text area for your manuscript must be 17 cm wide and 25 cm high (6.7 and 9.8 inches, resp.). Do not place any text outside this area. Use good quality, white paper of approximately 21 x 29 cm or 8 x 11 inches (please do not change the document setting from A4 to letter). Your manuscript will be reduced by approximately 20% by the publisher. Please keep this in mind when designing your figures and tables etc.